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To a solution of 9-[(4-methylphenyl)-thiocarboxyl acyl]-minocycline (170 g, allopurinol mode of action 280 mmol), Cu(I)-thiophenecarboxylate (0801 g, 420 mmol), Pd 2(dba) 3 (0064 g, 0070 mmol) and P(2-furyl) 3 (0-130 g, 0560 mmol) in anhydrous THF (5 mL) under argon was added a 01M solution of previously prepared (CH 3CH 2) 3In (560 mL, 560 mmol), then the solution was heated to reflux until reaction was complete.

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